Testosterone replacement therapy (TRT) is a common treatment for men with low testosterone levels (low T). There are various methods of injection administration, it is used mostly for its effectiveness, accessibility and accurate dosage.

 Types of testosterone injections

Testosterone injections, according to induction, are two main forms.
1. Intramuscular injection (IM): It is injected deep into the butt, lower back, shoulder or thigh. Use complex testosterone excretions such as testosterone énanthate, cypionate, or non-cortical. The injection site is switched to avoid discomfort and scars.

2. Subcutaneous injection (sub -q): It is injected into a fatty piece of your body just below the skin, typically into the abdomen or thighs. It uses a small needle, which reduces the pain of the process than IM injection. It provides more stable levels of testosterone and reduces variability.

 

Injection Frequency

The frequency of injections depends on the type of testosterone ester used:
  • Testosterone Enanthate & Cypionate – Typically injected once every 1–2 weeks (or smaller doses every few days).
  • Testosterone Undecanoate – A long-acting ester injected every 10–12 weeks, usually in a clinic.
  • Frequent low-dose protocols – some patients inject every 2-3 days to maintain stable testosterone levels.

 

Advantages and disadvantages of injection

Pros:
  • It is very effective when absorbed directly into the blood circulation.
  • Effective compared to other TRT methods.
  • The flexible dosage allows personalized treatment.

 

Cons:
  • Regular injections are required, and some may find it uncomfortable.
  • Possible hormonal fluctuations when the dosage is too far.
  • Possible mild side effects, such as irritation at the injection site.